Featured Publications
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“The Role of Autophagy in the Mineralization Process of Bone and Dentin.”
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“DMP1-mediated transformation of DPSCs to CD31+/CD144+ cells demonstrate endothelial phenotype both in vitro and in vivo.”
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“Role of DMP1-mediated GRP78 activation in osteoimmunomodulation of periodontal ligament stem cells.”
Publications Through the Years
Publications Through the Years
2026
- Alhamad, M., Chen, Y., Kanniyappan, H., George A., et al. Cell Accelerated Corrosion (CAC) on the Dental Implant: An Exploratory Study with Gingival Fibroblasts and Macrophages. J Bio Tribo Corros 12, 8 (2026). https://doi-org.proxy.cc.uic.edu/10.1007/s40735-025-01062-0
2025
- Valverde A, Naqvi RA, Chen Y, Moshaverinia A, George A, Shukla D, Martinez G, Chapa G, Nares S, Naqvi AR. Herpesvirus Simplex Virus-1 Exploits Inflammation to Infect Periodontal Stem Cells and Disrupt Lineage Commitment. J Periodontal Res. 2025 Dec;60(12):1265-1279. doi: 10.1111/jre.70022. Epub 2025 Jul 29. PMID: 40728191; PMCID: PMC12881881.
- Moran I, Villani C, George A. The Role of Autophagy in the Mineralization Process of Bone and Dentin. Int J Mol Sci. 2025 Jun 29;26(13):6278. doi: 10.3390/ijms26136278. PMID: 40650055; PMCID: PMC12250005.
- Valverde A, George A, Nares S, Naqvi AR. Emerging therapeutic strategies targeting bone signaling pathways in periodontitis. J Periodontal Res. 2025 Feb;60(2):101-120. doi: 10.1111/jre.13326. Epub 2024 Jul 23. PMID: 39044454; PMCID: PMC11873684.
- Delle Monache S, Pulcini F and George A (2025) Editorial: Advances in dental pulp stem cell biology and applications. Front. Cell Dev. Biol. 13:1695340. doi: 10.3389/fcell.2025.1695340
- Lamarque GCC, Leme RD, Almeida Junior LA, Lucisano MP, Bombonato-Prado KF, Segato RAB, George A, Paula-Silva FWG. Effects triggered by tumor necrosis factor-α in immortalized murine dental pulp and pre-osteoblastic cells. Braz Oral Res. 2025 Sep 8;39:e087. doi: 10.1590/1807-3107bor-2025.vol39.087. PMID: 40929406; PMCID: PMC12419187.
- Ganapathy A, Chen Y, Bakthavachalam V and George A (2025) DMP1-mediated transformation of DPSCs to CD31+/CD144+ cells demonstrate endothelial phenotype both in vitro and in vivo. Front. Cell Dev. Biol. 13:1630129. doi: 10.3389/fcell.2025.1630129
2024
- Ganapathy A, Narayanan K, Chen Y, Villani C and George A (2024) Dentin matrix protein 1 and HUVEC-ECM scaffold promote the differentiation of human dental pulp stem cells into endothelial lineage: implications in regenerative medicine. Front. Physiol. 15:1429247. doi: 10.3389/fphys.2024.1429247
- Prasathkumar M, George A, Sadhasivam S. Influence of chitosan and hydroxyethyl cellulose modifications towards the design of cross-linked double networks hydrogel for diabetic wound healing. Int J Biol Macromol. 2024 Apr;265(Pt 1):130851. doi: 10.1016/j.ijbiomac.2024.130851. Epub 2024 Mar 13. PMID: 38484821.
- Villani C, Murugan P, George A. Exosome-Laden Hydrogels as Promising Carriers for Oral and Bone Tissue Engineering: Insight into Cell-Free Drug Delivery. Int J Mol Sci. 2024 Oct 15;25(20):11092. doi: 10.3390/ijms252011092. PMID: 39456873; PMCID: PMC11508290.
- Villani C, Chen Y, George A. Role of DMP1-mediated GRP78 activation in osteoimmunomodulation of periodontal ligament stem cells. J Struct Biol. 2024 Dec;216(4):108133. doi: 10.1016/j.jsb.2024.108133. Epub 2024 Oct 9. PMID: 39389243; PMCID: PMC12067943.
- Chen Y, Villani C, Ganapathy A, George A. Transcriptome profiling of DPP stimulated DPSCs identifies the role of autophagy in odontogenic differentiation. J Struct Biol. 2024 Dec;216(4):108134. doi: 10.1016/j.jsb.2024.108134. Epub 2024 Oct 9. PMID: 39389242; PMCID: PMC12065480.
- Chen, Y., Petho, A., Ganapathy, A., George, A., et al. DPP an extracellular matrix molecule induces Wnt5a mediated signaling to promote the differentiation of adult stem cells into odontogenic lineage. Sci Rep 14, 26187 (2024). https://doi.org/10.1038/s41598-024-76069-7
2023
- Merkel A, Chen Y, Villani C, George A. GRP78 promotes the osteogenic and angiogenic response in periodontal ligament stem cells. Eur Cell Mater. 2023 Jan 23;45:14-30. doi: 10.22203/eCM.v045a02. PMID: 36683528; PMCID: PMC10243372.
- Ouchi T, Orsini G, Kajiya M and George A (2023) Editorial: Stem cells in oral cavity: from development to regeneration, Volume II. Front. Cell Dev. Biol. 11:1207744. doi: 10.3389/fcell.2023.1207744.
- Kim, J. H., Irfan, M., Hossain, M. A., Shin, S., George, A., & Chung, S. (2023). LPS-induced inflammation potentiates dental pulp stem cell odontogenic differentiation through C5aR and p38. Connective Tissue Research, 64(5), 505–515.
- Arivalagan, J.; Ganapathy, A.; Kalishwaralal, K.; Chen, Y.; George, A. Insights into the Structure and Function of TRIP-1, a Newly Identified Member in Calcified Tissues. Biomolecules 2023, 13, 412.
- Kim, J.-H.; Irfan, M.; Hossain, M.A.; George, A.; Chung, S. BDNF/TrkB Is a Crucial Regulator in the Inflammation-Mediated Odontoblastic Differentiation of Dental Pulp Stem Cells. Cells 2023, 12, 1851.
- Guirado, E., Villani, C., Petho, A., George, A., et al. Wnt pathway inhibitors are upregulated in XLH dental pulp cells in response to odontogenic differentiation. Int J Oral Sci 15, 13 (2023). https://doi.org/10.1038/s41368-022-00214-z
- Carpenter, K.A., Alkhatib, D.O., Dulion, B.A., George, A., et al. Sclerostin antibody improves alveolar bone quality in the Hyp mouse model of X-linked hypophosphatemia (XLH). Int J Oral Sci 15, 47 (2023).
2022
- Pasiewicz, R., Valverde, Y., Narayanan, R., Kim, J. H., Irfan., George, A., M., Lee, N. S., … Chung, S. (2022). C5a complement receptor modulates odontogenic dental pulp stem cell differentiation under hypoxia. Connective Tissue Research, 63(4), 339–348. https://doi.org/10.1080/03008207.2021.1924696
- Ouchi T, Orsini G, George A and Kajiya M (2022) Editorial: Stem Cells in Oral Cavity: From Development to Regeneration. Front. Cell Dev. Biol. 10:840771. doi: 10.3389/fcell.2022.840771
- Naqvi RA, Gupta M, George A, Naqvi AR. MicroRNAs in shaping the resolution phase of inflammation. Semin Cell Dev Biol. 2022 Apr;124:48-62. doi: 10.1016/j.semcdb.2021.03.019. Epub 2021 Apr 29. PMID: 33934990; PMCID: PMC8553811.
- Irfan, M., Kim, JH., Marzban, H., George, A., et al. The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation. Int J Oral Sci 14, 7 (2022).
2021
- Merkel, Annette C., George A., et al. “Non-collagenous ECM Matrix Components Growth Factors and Cytokines Involved in Matrix Mineralization.” Extracellular Matrix Biomineralization of Dental Tissue Structures (2021): n. pag.
- Chen Y, Koshy R, Guirado E, George A. STIM1 a calcium sensor promotes the assembly of an ECM that contains Extracellular vesicles and factors that modulate mineralization. Acta Biomater. 2021 Jan 15;120:224-239. doi: 10.1016/j.actbio.2020.10.011. Epub 2020 Oct 29. PMID: 33130308; PMCID: PMC7796999.
- Jing H, Pálmai M, Saed B, George A, Snee PT, Hu YS. Cytosolic delivery of membrane-penetrating QDs into T cell lymphocytes: implications in immunotherapy and drug delivery. Nanoscale. 2021 Mar 18;13(10):5519-5529. doi: 10.1039/d0nr08362c. PMID: 33688882; PMCID: PMC8029070.
- S Prakash Parthiban, George A., et al 2021 Biofabrication 13 035031
- E. Guirado, A. George. Dentine matrix metalloproteinases as potential mediators of dentine regeneration. Eur Cell Mater. 2021, 42, 392-400.
- Moradian-Oldak J, George A. Biomineralization of Enamel and Dentin Mediated by Matrix Proteins. J Dent Res. 2021 Sep;100(10):1020-1029. doi: 10.1177/00220345211018405. Epub 2021 Jun 21. PMID: 34151644; PMCID: PMC8381691.
- Kongkiatkamon, S.; Ramachandran, A.; Knoernschild, K.L.; Campbell, S.D.; Sukotjo, C.; George, A. Dentin Matrix Protein 1 on Titanium Surface Facilitates Osteogenic Differentiation of Stem Cells. Molecules 2021, 26, 6756.
- Chen Y, Pethö A, Ganapathy A, George A. DPP promotes odontogenic differentiation of DPSCs through NF-κB signaling. Sci Rep. 2021 Nov 11;11(1):22076. doi: 10.1038/s41598-021-01359-3. PMID: 34764323; PMCID: PMC8586344.
2020
- Guirado E, Chen Y, Ross RD, Zhang Y, Chaussain C and George A (2020) Disrupted Protein Expression and Altered Proteolytic Events in Hypophosphatemic Dentin Can Be Rescued by Dentin Matrix Protein 1. Front. Physiol. 11:82. doi: 10.3389/fphys.2020.00082
- Huang CC, Ravindran S, Kang M, Cooper LF, George A. Engineering a Self-Assembling Leucine Zipper Hydrogel System with Function-Specific Motifs for Tissue Regeneration. ACS Biomater Sci Eng. 2020 May 11;6(5):2913-2928. doi: 10.1021/acsbiomaterials.0c00026. Epub 2020 Apr 7. PMID: 33463282; PMCID: PMC8080846.
- Ghosh S, Chen Y, George A, Dutta M and Stroscio MA (2020) Fluorescence Resonant Energy Transfer-Based Quantum Dot Sensor for the Detection of Calcium Ions. Front. Chem. 8:594. doi: 10.3389/fchem.2020.00594
- Ghosh, S., Chen, Y., Sebastian, J., George A, et al. A study on the response of FRET based DNA aptasensors in intracellular environment. Sci Rep 10, 13250 (2020). https://doi.org/10.1038/s41598-020-70261-1
2019
- Guirado E, Zhang Y, George A. Establishment of Stable Cell Lines from Primary Human Dental Pulp Stem Cells. Methods Mol Biol. 2019;1922:21-27. doi: 10.1007/978-1-4939-9012-2_3. PMID: 30838561; PMCID: PMC6500575.
- Merkel A, George A. In Vitro Analysis of Intramolecular Signaling Events in PDLSCs Using Confocal and TIRF Microscopy. Methods Mol Biol. 2019;1922:103-110. doi: 10.1007/978-1-4939-9012-2_10. PMID: 30838568; PMCID: PMC6504966.
- Chmilewsky F, Liang R, Kanazawa M, About I, Cooper LF, George A. C5L2 Regulates DMP1 Expression during Odontoblastic Differentiation. J Dent Res. 2019 May;98(5):597-604. doi: 10.1177/0022034518820461. Epub 2019 Jan 31. PMID: 30702959; PMCID: PMC6481006.
- P.Figueiredo, M. H.Sipponen, K.Lintinen, A.Correia, A.Kiriazis, J.Yli-Kauhaluoma, M.Österberg, A.George, J.Hirvonen, M. A.Kostiainen, H. A.Santos, Preparation and Characterization of Dentin Phosphophoryn-Derived Peptide-Functionalized Lignin Nanoparticles for Enhanced Cellular Uptake. Small2019, 15, 1901427.
- Merkel A, Chen Y and George A (2019) Endocytic Trafficking of DMP1 and GRP78 Complex Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells. Front. Physiol. 10:1175. doi: 10.3389/fphys.2019.01175
2018
- Pethő A, Chen Y, George A. Exosomes in Extracellular Matrix Bone Biology. Curr Osteoporos Rep. 2018 Feb;16(1):58-64. doi: 10.1007/s11914-018-0419-y. PMID: 29372401; PMCID: PMC5812795.
- Trino LD, Bronze-Uhle ES, Ramachandran A, Lisboa-Filho PN, Mathew MT, George A. Titanium surface bio-functionalization using osteogenic peptides: Surface chemistry, biocompatibility, corrosion and tribocorrosion aspects. J Mech Behav Biomed Mater. 2018 May;81:26-38. doi: 10.1016/j.jmbbm.2018.02.024. Epub 2018 Feb 21. PMID: 29477893; PMCID: PMC5871601.
- Luciana D. Trino, Erika S. Bronze-Uhle, Anne George, Mathew T. Mathew, Paulo N. Lisboa-Filho,
Surface Physicochemical and Structural Analysis of Functionalized Titanium Dioxide Films,
Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 546, 2018, Pages 168-178, ISSN 0927-7757 - Chen Y and George A (2018) TRIP-1 Promotes the Assembly of an ECM That Contains Extracellular Vesicles and Factors That Modulate Angiogenesis. Front. Physiol. 9:1092. doi: 10.3389/fphys.2018.01092
- Ramachandran A, He K, Huang CC, Shahbazian-Yassar R, Shokuhfar T, George A. TRIP-1 in the extracellular matrix promotes nucleation of calcium phosphate polymorphs. Connect Tissue Res. 2018 Dec;59(sup1):13-19. doi: 10.1080/03008207.2018.1424146. PMID: 29745814.
- Chen Y, Ramachandran A, Zhang Y, Koshy R, George A. The ER Ca2+ sensor STIM1 can activate osteoblast and odontoblast differentiation in mineralized tissues. Connect Tissue Res. 2018 Dec;59(sup1):6-12. doi: 10.1080/03008207.2017.1408601. PMID: 29745808; PMCID: PMC6309428.
- Luciana D. Trino, Luiz G.S. Albano, Erika S. Bronze-Uhle, Anne George, Mathew T. Mathew, Paulo N. Lisboa-Filho,
Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applications, Ceramics International, Volume 44, Issue 17, 2018, Pages 21004-21014, ISSN 0272-8842
2017
- Maurizio Ventre, Valerio Coppola, Maria Iannone, Paolo A. Netti, Ismaiel Tekko, Eneko Larrañeta, Aoife M. Rodgers, Christopher J. Scott, Adrien Kissenpfennig, Ryan F. Donnelly, Shaheer Maher, Dusan Losic, Anne George, Amsaveni Ramachandran,
Chapter 2 – Nanotechnologies for tissue engineering and regeneration, Editor(s): Vuk Uskoković, Dragan P. Uskoković,
In Micro and Nano Technologies, Nanotechnologies in Preventive and Regenerative Medicine, Elsevier, 2018, Pages 93-206,
ISBN 9780323480635 - George A and Ravindran S, MRI of Engineered Dental and Craniofacial Tissues, Magnetic Resonance Imaging in Tissue Engineering, 2017, 10.1002/9781119193272
2016
- Chen Y, Zhang Y, Ramachandran A, George A. DSPP Is Essential for Normal Development of the Dental-Craniofacial Complex. J Dent Res. 2016 Mar;95(3):302-10. doi: 10.1177/0022034515610768. Epub 2015 Oct 26. PMID: 26503913; PMCID: PMC4766953.
- Ramachandran, A., Ravindran, S., Huang, CC, George A. et al. TGF beta receptor II interacting protein-1, an intracellular protein has an extracellular role as a modulator of matrix mineralization. Sci Rep 6, 37885 (2016).
2015
- Ravindran S and George A (2015) Biomimetic extracellular matrix mediated somatic stem cell differentiation: applications in dental pulp tissue regeneration. Front. Physiol. 6:118. doi: 10.3389/fphys.2015.00118
- Eapen A and George A (2015) Dentin phosphophoryn in the matrix activates AKT and mTOR signaling pathway to promote preodontoblast survival and differentiation. Front. Physiol. 6:221. doi: 10.3389/fphys.2015.00221
- Ravindran S, George A. Dentin Matrix Proteins in Bone Tissue Engineering. Adv Exp Med Biol. 2015;881:129-42. doi: 10.1007/978-3-319-22345-2_8. PMID: 26545748; PMCID: PMC4755351.
- Padovano JD, Ravindran S, Snee PT, Ramachandran A, Bedran-Russo AK, George A. DMP1-derived peptides promote remineralization of human dentin. J Dent Res. 2015 Apr;94(4):608-14. doi: 10.1177/0022034515572441. Epub 2015 Feb 18. PMID: 25694469; PMCID: PMC4485220.
- Ravindran S, Kotecha M, Huang CC, Ye A, Pothirajan P, Yin Z, Magin R, George A. Biological and MRI characterization of biomimetic ECM scaffolds for cartilage tissue regeneration. Biomaterials. 2015 Dec;71:58-70. doi: 10.1016/j.biomaterials.2015.08.030. Epub 2015 Aug 20. PMID: 26318817; PMCID: PMC4572912.